It’s been an interesting couple of months here at disrupt.vet—in July I developed a random and still unexplained empyema (pyothorax) which needed a thoracotomy to resolve, followed by a road trip to Melbourne for uni (I wasn’t allowed to fly after the thoracotomy), and then a major presentation on wellbeing for AEA Next ’19. Things are slowly settling back to our version of ‘normal’, and I’ve even been cleared by my many, many, doctors to start rehab to eventually get back to work.
One of the things I’ve noticed since my fun little empyema experience, is that my mental health has been poor, and my emotions extremely dysregulated. Now this is within the range of “normal” for me—I have comorbid diagnoses of Autism, ADHD, social and generalised anxiety. Emotional dysregulation, anxiety and depression are common in neurodivergent individuals. But all my normal self-care and behavioural management strategies are currently ineffective. Which led me to wonder, why do strategies that have worked for decades, and have good empirical evidence to support them, suddenly stop working?
I got a clue to the answer while talking to my infectious disease doctor, who is still trying to figure out why the right side of my chest suddenly filled with pus. She’s concerned that my microbiome might have been disrupted, back in 2017 when I was on weeks of intravenous antibiotics for the xanthogranulomatous pyelonephritis that eventually cost me my right kidney. Of course, I was also on two weeks of IV AB in July after my pleural effusion was diagnosis as empyema. The ID doc specifically asked about my mental health since that time—because changes in affect (positive and negative emotion), anxiety and depression can be triggered by disruptions in the gut microbiota! So she’s ordered RNA microbiome testing because that’s the most reliable snapshot we can currently get of the bacteria, viruses, archaea, yeast, fungi, and eukaryotes living in the gut. It’s limited in that it doesn’t give a specific analysis of the mucosal surface layer of each section of the GIT—but the overview can be useful.
So now we’re waiting on those reports, and I’m fascinated to see the results. The published literature linking mental illness and disrupted gut flora is growing. I wonder what that means for veterinarians, a group exposed to both excessive hygiene practices and a wide range of zoonotic bacteria?
